what happens to chylomicron remnants
1997. What does CR stand for? After a fatty meal, the blood is so full of chylomicrons that it looks milky. In the perfused liver the uptake of 126I-labelled chylomicron remnants has been described by Noel etal. The small particles are remnants. Abstract. After chylomicron remnants, what is left? 16, No. Chylomicron: A small fat globule composed of protein and lipid (fat). Setting : An 800 bed general municipal hospital. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver. chylomicron remnants partially metabolized chylomicrons that have lost most of their triglycerides via degradation in muscle and adipose tissue but retain their cholesteryl esters; they reenter the bloodstream and are taken up into hepatic cells via receptor-mediated endocytosis. Their compo- sition was characterized by investigators in several labo- ratories. Recently, gene targeting has been applied to generate mouse models with deficiencies in lipoprotein metabolism and to dissect the chylomicron remnant clearance pathway in vivo. "Chylomicron Remnants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. ... by loosing Apo CII, the remnants are able to exit the capillaries and they travel to the liver, where they bind to either LRP receptors or LDL receptors once bound to the receptor, it is taken in … These experiments, together with studies performed in cultured cells, have demonstrated that plasma clearance of chylomicron remnants is a two-step process. Notice the apoB48 and B100 apoproteins on the appropriate remnant. cofactor for membrane-bound lipoprotein lipase which breaks down TAGs in chylomicron. A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. Rat lymph chylomicrons and chylomicron remnants were treated with trypsin or Pronase. (1997). Moreover, the density of a chylomicron is <0.930 g/ml while the density of a VLDL is 0.930- 1.006 g/ml. The other plasma lipids are derived from food or enter the plasma from tissue sites. This page provides all possible translations of the word chylomicron remnants in the Tamil language. LDL (low-density lipoprotein) plays a major role in foam cell formation, although prior oxidation of the particles is required. (1975) havealso shown substantial uptake ofremnanttriacylglycerol. Rats were fed corn oil to induce production and secretion of chylomicrons and were then injected with polyclonal antiserum raised against hepatic lipase to specifically and quantitatively inhibit hepatic lipase activity in vivo. Kenji Higashi, Toshitsugu Ishikawa, Hideki Shige, Koji Tomiyasu, Hiroshi Yoshida, Toshimitsu Ito, Kei Nakajima, Atsushi Yonemura, Syojiro Sawada, Barno Nakamura. Objective : To test the hypothesis that subjects who clear chylomicron remnants slowly from plasma may be at higher risk of coronary artery disease than indicated by their fasting plasma lipid concentrations. The ability of the resulting apoprotein-free lipoproteins to be taken up by the isolated perfused rat liver, and to bind to isolated rat liver membranes, was examined. Chylomicron remnants were removed at a rate of ~50% per pass in WT mice. The resulting chylomicron remnants, which are cholesterol-rich lipoproteins, are subsequently taken up in the liver. Chylomicron remnants bound to rabbit alveolar macrophages with high-affinity (Kd = 3.3 ± 0.71 μg of protein/mL). Chylomicron: A lipoprotein rich in triglyceride and common in the blood during fat digestion and assimilation. Olive oil increases the magnitude of postprandial chylomicron remnants compared to milk fat and safflower oil. Design : Case control study over three years. Major Apoproteins for chylomicron metabolism was directly established by Trevor Redgrave (9) who demonstrated the accumula- tion of cholesteryl ester-rich particles in the blood of functionally hepatectomized rats and coined the term chylomicron remnants for these particles. Density. pro-atherogenic chylomicron remnants in plasma. Very low-density lipoprotein, or VLDL: Produced primarily by the liver, with smaller amounts contributed by the intestine. To gain a detailed understanding of those factors that govern the processing of dietary-derived lipoprotein remnants by macrophages we examined the uptake and degradation of rat triacylglycerol-rich chylomicron remnants and rat cholesterol-rich beta-very low density lipoprotein (beta-VLDL) by J774 cells and primary cultures of mouse peritoneal macrophages. 5, pp. We've got 0 rhyming words for chylomicron remnants » What rhymes with chylomicron remnants? nants Would you like to know how to translate chylomicron remnants to Tamil? The small circle at the top left represents a chylomicron remnant (CMR) and the one just below it is the remnant of VLDL called intermediate density lipoprotein (LDL). "Chylomicron Remnants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.
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